Telling stories through geography is one of Rockstar's underrated artistic tools.
Examples
GTA San Andreas using the neighbourhood-as-character trope (Grove Street vs Ballas territory). GTA V using Los Santos's income inequality. RDR2 using west-as-frontier. Each map tells a story without saying a word.
Expect GTA 6 to replicate this too - Vice City's modern-day inequity, the wetlands = off the grid, the Keys = escape territory.