Three drives span the entire map. This is our speculative, pre-launch take.
Vice City to the Keys
Driving down through the Keys. See the Keys bridge route page for more on driving the bridges. The most distinctive single drive.
Vice City to the inland small towns
Heading north through the suburbs, then into the rural towns. A multi-stage shift from city to suburbs to country. The inland crossing.
Vice City through the wetlands
Go west or north-west through the Everglades-coded area. Different look. Slower pace.