Strip clubs have been part of GTA dating back to at least Vice City in 2002. Their depiction has varied between eras - more graphic in some games, toned down in others. Trailer 2 confirms that this category of content exists in GTA 6.
This piece focuses on the nightlife beat. See also the night clubs piece for broader club content.
What the trailer shows
Interior shots of a strip-club-coded environment - dim lighting, neon, bartenders, patrons, dancers. More of a beat than a sustained scene. The composition stays true to the established GTA strip-club aesthetic.
It's unknown if the venue is a story-mission location, a side-content spot, or both.
How GTA has handled this content historically
GTA: Vice City (2002) featured explicit strip-club content. GTA San Andreas featured it as well. GTA IV added The Triangle Club as a side location. GTA V features two strip clubs, one of which (the Vanilla Unicorn) is both a story mission location and a recurring side location. Mechanics have changed from game to game and region to region, and some content has been censored in certain markets.
At minimum, expect GTA 6 strip clubs to follow the GTA V pattern - venues are present, accessible, and included in at least one story beat.
What we don't know yet
How many are there? Where are they on the map? Are they locked behind mission progression or freely accessible? Do regional versions tone them down? Are there any mechanics beyond observing the environment and paying for services?
Updates will be posted as more becomes available.